The Impact of 5-HTTLPR Polymorphism on Depression and Lymphocyte Changes in Colorectal Cancer Patients Undergoing FOLFOX Chemotherapy
Changes in the percentage of CD4+ cells and CD16/56+ cells under depression were moderated by 5-HTTLPR alleles among CRC patients undergoing FOLFOX chemotherapy, suggesting a gene-environment interaction. Further research on the role of 5-HTTLPR in the immune system under depression among CRC patients is warranted.
Authors
- Ju Yeon Lee
- Woo Kyun Bae
- Hyun-Woo Choi (ORCID: https://orcid.org/0000-0002-9438-1603)
- Il-Seon Shin
- Hee-ju Kang
- Sung-Wan Kim
- Seunghyong Ryu
- Hyun-Jeong Shim
- Min Jhon
- Jae-Min Kim
- Seon-Young Kim
Institutions
- Chonnam National University (KR)
- Chonnam National University Hwasun Hospital (KR)
Publication Details
- Journal
- Psychiatry Investigation
- Published
- 2026-01-20
- DOI
- https://doi.org/10.30773/pi.2025.0267
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Ministry of Science, ICT and Future Planning
- Ministry of Science and ICT, South Korea