Exceptional long-term survival in pulmonary large-cell neuroendocrine carcinoma with brain metastases: a case report
This case demonstrates that prolonged survival in stage IV LCNEC with brain metastases is possible through individualized multimodal therapy and close longitudinal monitoring. It underscores the potential value of molecular profiling and biomarkers like PRO-GRP in treatment planning and disease tracking.
Authors
- L Z Zhang
- Hua Wang (ORCID: https://orcid.org/0000-0002-5728-7714)
- Bin Liu
Institutions
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3389/fonc.2026.1631889
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00