Heterogeneous DNA methylation and gene expression patterns underly metabolic plasticity in canine astrocytoma-derived stem-like cells
Together, these data support that hypoxia enhances distinct stem-like traits in canine astrocytoma GSLCs, similar to human GSCs.
Authors
- Daniel York (ORCID: https://orcid.org/0000-0001-6286-2894)
- Maciej Parys (ORCID: https://orcid.org/0000-0003-4456-3369)
- Kevin Woolard (ORCID: https://orcid.org/0000-0003-3588-9359)
- Christine M. Toedebusch (ORCID: https://orcid.org/0000-0002-3216-3344)
- Shafee Syed-Quadri
- Frederick J. Meyers (ORCID: https://orcid.org/0000-0002-4456-4647)
- Alexander J. Heese
- Orwa Aboud
- Peter Dickinson
- John D. McPherson
- Chang-il Hwang
Institutions
- Roslin Institute (GB)
- Precision for Medicine (United States) (US)
- Institute of Molecular Genetics (RU)
- Neurological Surgery (US)
- UC Davis Comprehensive Cancer Center
- University of California, Davis (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3389/fonc.2025.1690414
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- University of California, Davis
- National Cancer Institute
- Center for Companion Animal Health, University of California, Davis