Pulcherriminic acid relay; a Bacilli route to attack pathogens

Pulcherriminic acid (PA) relay is a recently discovered phenomenon in which the <i>Bacillus subtilis</i> employs branching biofilms to relay the antimicrobial pigment, pulcherriminic acid towards the pathogen. PA interacts with the free iron in the environment to form the reddish-pink pigment, pulcherimin, which subsequently accumulates on the pathogen depriving them of the essential iron. In <i>Staphylococcus aureus</i>, the ferric uptake regulator (Fur) system plays a vital role in maintaining iron homeostasis, virulence, and biofilm formation. The perspective article discusses the plausible mechanistic insights on the impact of PA relay in hampering the Fur system. Taken together, these findings highlight PA and PA-producing <i>Bacillus</i> species as a promising alternative for mitigating drug resistant <i>S. aureus</i> infections.