Mind the Gap: The Cognitive Blind Spot in Epilepsy

A Computer-Assisted Rehabilitation Program Improves Self-Management, Cognition, and Quality of Life in Epilepsy: A Randomized Controlled Trial Duzova US, Seflek Z, Eren F, Ozturk S, Tutar MF. Epilepsy Behav. 2025 Mar;164:110277. doi: 10.1016/j.yebeh.2025.110277. PMID: 39854830. Objective: This study aimed to evaluate the impact of a computer-assisted rehabilitation program on self-management, cognitive function, and quality of life in people with epilepsy (PwE). Methods: A randomized controlled trial was conducted with 44 PwE (22 intervention, 22 control) at a university hospital's neurology clinic. The intervention group received 12 sessions of the RehaCom program (45 min/session, twice a week for 6 weeks). Data were collected using the “Quality of Life in Epilepsy Inventory (QOLIE),” “Epilepsy Self-Management Scale (ESMS),” and “Moxo test” before and after the intervention. Results: The intervention group showed significant improvements in attention and timing dimensions of the MOXO test and reductions in hyperactivity symptoms compared to the control group ( P < 0.05). ESMS scores, including overall self-management, information management, lifestyle management, and safety management subdimensions, significantly increased. Similarly, QOLIE scores, particularly in cognitive functioning, emotional well-being, and energy/fatigue, improved, while seizure worry scores decreased ( P < 0.001). Significance: The computer-assisted rehabilitation program enhanced self-management, quality of life, attention, and responsiveness while reducing impulsivity and hyperactivity symptoms in PwE.