Population pharmacokinetic modeling of piperacillin in critically ill adult patients: consideration of sex-based differences during model development
This study is the first to consider sex-specific covariates during the modeling process for piperacillin in critically ill patients. This approach may help reduce differences in model predictions between males and females in model-informed precision dosing strategies.
Authors
- Amélie Marsot (ORCID: https://orcid.org/0000-0002-9303-8862)
- Bianca Beloin-Jubinville
- Nicolas Goettel
- David M. Williamson
- Hugues Blain (ORCID: https://orcid.org/0009-0009-9599-3589)
- Marc-André Smith
- Van Nguyen
- François Lamontagne
- Ibrahim El-Haffaf
- Alexandre Duong
- Martin Albert
Institutions
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Expert Review of Clinical Pharmacology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1080/17512433.2026.2620530
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00