Succinate-mediated activation of the GPR91/MALT1/NF-κB/CCL2 pathway in macrophages contributes to pulmonary fibrosis
Succinate triggers CCL2 release in macrophages via the GPR91/MALT1/NF-κB pathway, thereby exacerbating pulmonary fibrosis. These findings suggest that targeting succinate signaling may represent a novel therapeutic strategy for IPF.
Authors
- Mao Jiang (ORCID: https://orcid.org/0000-0002-0621-1349)
- Yijun He (ORCID: https://orcid.org/0000-0003-1152-2907)
- Jie Meng
- Xiangyu Zhang
- Guoliang Jiang
- Tingting Yao
- Honghui Yang
- Xiaoyun Cheng
- Lingzhi Long
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1016/j.intimp.2026.116213
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00