Targeting ADAR1-mediated RNA editing inhibits hepatic stellate cell activation and liver fibrosis by enhancing HSC-intrinsic innate immunity
ADAR1-imposed RNA editome suppresses HSC-intrinsic innate immunity and promotes collagen production, leading to aggravated HSC activation and liver fibrosis. Targeting ADAR1 with its pharmacological inhibitor or HSC-selective RNAi shows great promise in treating liver fibrosis.
Authors
- Lingyi Liu (ORCID: https://orcid.org/0000-0001-5601-221X)
- M Zhang
- D. Yang
- Pengfei Xu (ORCID: https://orcid.org/0000-0002-9401-9487)
- X Wang
- Yue Xi (ORCID: https://orcid.org/0000-0003-1265-6624)
- Songrong Ren (ORCID: https://orcid.org/0000-0001-6797-6188)
- Wen Xie
- Jong-Won Kim (ORCID: https://orcid.org/0009-0008-1219-6967)
- Meishu Xu
- Aizat Abdirassil
- Qingde Wang
Institutions
- University of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Gut
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1136/gutjnl-2025-335942
- Citations
- 1
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 22.24