Evolution of carbapenem-resistant Klebsiella pneumoniae after ceftolozane–tazobactam exposure in a patient after cord blood transplantation: A case report
This case demonstrates that K. pneumoniae without carbapenemase production can acquire carbapenem resistance through a combined resistance mechanisms following exposure to non-carbapenem antibiotics. Antimicrobial stewardship must be implemented comprehensively, not focused solely on specific antibiotics.
Authors
- Yoko Tateishi (ORCID: https://orcid.org/0000-0003-3150-5864)
- Yukihiro Yoshimura (ORCID: https://orcid.org/0000-0002-5046-7819)
- Kohji Komori (ORCID: https://orcid.org/0000-0001-9659-3186)
- Shuhei Kurosawa (ORCID: https://orcid.org/0000-0001-6426-6770)
- Tomonori Nakazato (ORCID: https://orcid.org/0000-0003-3579-4018)
- Yuki Iketani
- Kaworu Takatsuna
- H. Ike
- Sohei Harada
- Hiroyuki Hayashi
Institutions
- Toho University (JP)
- Yokohama Municipal Citizen's Hospital (JP)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1016/j.jgar.2026.01.008
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00