A two-sample Mendelian Randomization study on the causal relationship between obesity and breast cancer

This study provides robust genetic evidence that higher BMI and WC are inversely associated with breast cancer risk, especially ER + disease. These findings highlight the importance of considering adiposity type and tumor subtype in understanding breast cancer etiology and suggest distinct underlying mechanisms warranting further investigation. Importantly, these results do not support recommending weight gain for cancer prevention; rather, they underscore the need for balanced health strategies that consider multiple risk factors.

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Publication Details

Journal
Clinical Nutrition ESPEN
Published
2026-01-19
DOI
https://doi.org/10.1016/j.clnesp.2026.102925
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

A two-sample Mendelian Randomization study on the causal relationship between obesity and breast cancer

Yingxuan FU, Xu Yan, Hanjun Ma, Zhonggang Wu et al.
Clinical Nutrition ESPEN
Genetic Associations and Epidemiology
article

A two-sample Mendelian Randomization study on the causal relationship between obesity and breast cancer

Yingxuan FU, Xu Yan, Hanjun Ma, Zhonggang Wu, Shibo Zhao, Huaiyuan Zheng, An Yan, Xinyi Chen
article en

Abstract

This study provides robust genetic evidence that higher BMI and WC are inversely associated with breast cancer risk, especially ER + disease. These findings highlight the importance of considering adiposity type and tumor subtype in understanding breast cancer etiology and suggest distinct underlying mechanisms warranting further investigation. Importantly, these results do not support recommending weight gain for cancer prevention; rather, they underscore the need for balanced health strategies that consider multiple risk factors.

Clinical Nutrition ESPENVol. 72
Huaihua University (CN), Central South University (CN), Guangxi University (CN), Guangxi Medical University (CN), Guangxi University of Chinese Medicine (CN), Affiliated Hospital of Youjiang Medical University for Nationalities (CN), The Second Nanning People's Hospital (CN), Rongcheng City People's Hospital (CN), Third Xiangya Hospital (CN), University of South China (CN)
Openalex Percentile: Top 85%
Genetic Associations and Epidemiology
DOIOpen Access PDFOpenAlex
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A two-sample Mendelian Randomization study on the causal relationship between obesity and breast cancer — Yingxuan FU, Xu Yan, et al. · Clinical Nutrition ESPEN (2026) | TGRS Research Map | TGRS