Integrated multi-omics analysis of prognostic model and immune microenvironment in intrahepatic cholangiocarcinoma

This study establishes a prognostic model based on five key genes and elucidates their role in the immunosuppressive TME. MT1X was validated as a pro-tumorigenic factor, highlighting its potential as a therapeutic target.

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Publication Details

Journal
Translational Oncology
Published
2026-01-19
DOI
https://doi.org/10.1016/j.tranon.2026.102675
Primary Topic
Cholangiocarcinoma and Gallbladder Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Integrated multi-omics analysis of prognostic model and immune microenvironment in intrahepatic cholangiocarcinoma

Huijie Lu, Die Li, Xiangbao Yin, Yixian Wang et al.
Translational Oncology
Cholangiocarcinoma and Gallbladder Cancer Studies
article

Integrated multi-omics analysis of prognostic model and immune microenvironment in intrahepatic cholangiocarcinoma

Huijie Lu, Die Li, Xiangbao Yin, Yixian Wang, Junwen Hu, Mingming Wu, Xi Li
article en

Abstract

This study establishes a prognostic model based on five key genes and elucidates their role in the immunosuppressive TME. MT1X was validated as a pro-tumorigenic factor, highlighting its potential as a therapeutic target.

Translational OncologyVol. 65
Nanchang University (CN), First Affiliated Hospital of Jiangxi Medical College (CN), Second Affiliated Hospital of Nanchang University (CN), First Affiliated Hospital of Nanchang University (CN)
Good health and well-being
Openalex Percentile: Top 84%
Cholangiocarcinoma and Gallbladder Cancer Studies
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