Rapid Antimicrobial Resistance Detection Methods in Solid Organ Transplant Recipients

Antimicrobial resistance (AMR) is an escalating worldwide public health concern. Solid organ transplant recipients (SOTR) are disproportionately impacted by infection with multidrug-resistant bacteria, which has been associated with heightened morbidity and mortality in this population. Recent advances in AMR detection have given rise to the development of diagnostic assays capable of rapid AMR detection from clinical specimens. In the general population, many of these tests have been rigorously evaluated and are becoming increasingly incorporated into clinical diagnostic workflows. Data on the performance and clinical utility of assays for rapid AMR detection in SOTR are emerging, though they remain sparse compared to the general population. We provide an overview of Food and Drug Administration-approved, commercially available tests for rapid AMR detection, and review the available evidence regarding their performance and utility in SOTR.