Prognostic value of human serum alpha-klotho concentrations in patients with heart failure with reduced ejection fraction
Patients with higher serum α-klotho concentrations were associated with lower log-NT-proBNP levels and better 5-year survival in all patients as well as in patients with heart failure, compared to those with lower. These findings support the role of α-klotho as a promising cardioprotective biomarker for risk stratification in patients with HF.
Authors
- Jennifer Wilcox (ORCID: https://orcid.org/0000-0001-6277-1079)
- Ajay Mahenthiran
- Wen Tang (ORCID: https://orcid.org/0000-0002-2015-7625)
- Chia‐Feng Liu (ORCID: https://orcid.org/0000-0002-9383-341X)
- Steven Leon
- Silvio Augusto Nunes
Institutions
- Cleveland Clinic (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Clinical Biochemistry
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1016/j.clinbiochem.2026.111086
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00