Tumor-stroma contributes to immunotherapeutic resistance in non-small cell lung cancer via SEMA3C-mediated immunosuppressive tumor microenvironment
TSP served as an independent prognostic biomarker and predictor of ICB resistance in NSCLC. SEMA3C was identified as a crucial mediator within this axis, promoting tumor malignancy and fostering an immunosuppressive TME characterized by stromal remodeling and excluded anti-tumor immunity. This study established TSP as a clinically relevant stratification tool and revealed stromal-immune crosstalk.
Authors
- Qing Li
- Jian Wang
- Hongxin Lin
- Yun Cai
- Jie Mei
- Yichao Zhu
- Huanyan Zhang
- Qian Wang
- Di Wu
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Jintan People's Hospital (CN)
- Xuzhou Central Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1016/j.tranon.2026.102679
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 24.20