Cannabidiol modulates exosomal miRNA networks to enhance Imatinib mesylate response in chronic myelogenous leukemia
Circulating miRNAs are valuable biomarkers for TKI resistance in CML. Targeting HMGB1-associated miRNAs, together with combined CBD and IM treatment, may help re-establish apoptotic regulation and overcome resistance mechanisms.
Authors
- Svetla Danova (ORCID: https://orcid.org/0000-0001-5819-2904)
- Tsvetelina Paunova‐Krasteva (ORCID: https://orcid.org/0000-0002-8376-8917)
- Evelina Yordanova Vasileva
- Petar Petrov Donchev
Institutions
- Bulgarian Academy of Sciences (BG)
- Stephan Angeloff Institute of Microbiology (BG)
- Sofia University "St. Kliment Ohridski" (BG)
Publication Details
- Journal
- Global Medical Genetics
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1016/j.gmg.2026.100094
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00