Development and comparison of multivariate diagnostic models for rapidly progressive central precocious puberty in girls: the role of serum osteocalcin
The inclusion of OC helps improve the predictive performance of the model. For the diagnosis of RP-CPP in girls, a model can be chosen that includes the duration of breast development, serum OC levels, mean ovarian volume, endometrial presence/absence, and breast Tanner staging. However, all samples were from a single center, and multicenter validation is still needed.
Authors
- Dan Lan (ORCID: https://orcid.org/0000-0001-5899-7040)
- Lingfang Zeng (ORCID: https://orcid.org/0000-0003-3130-3015)
- Wei Qin (ORCID: https://orcid.org/0009-0000-5615-3151)
- Runqi Wang (ORCID: https://orcid.org/0000-0003-0800-3954)
- Ziting Ding
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- First People's Hospital of Nanning (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-19
- DOI
- https://doi.org/10.3389/fendo.2025.1728132
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00