Total flavonoids isolated from Fructus Mume (Prunus mume Sieb. et Zucc.) mitigate Parkinson's disease progression by promoting neuronal mitophagy via activation of the CaMKKβ/AMPK signaling pathway
FMF promotes neuronal mitophagy to exert the neuroprotective effects by activating the CaMKKβ/AMPK signaling pathway. These findings provide a theoretical foundation for the application of FM in the treatment of PD and promote the clinical application of FM.
Authors
- Xiaotao Feng
- Mengjie Sun (ORCID: https://orcid.org/0000-0003-0506-2721)
- Lizhen Huang (ORCID: https://orcid.org/0000-0001-6397-9111)
- Xiangdong Lu
- Chunling Wang
- Wentao Zhang
- Mengyuan Gao
- Xiaodong Wen
Institutions
- Guangxi University (CN)
- Guangxi University of Chinese Medicine (CN)
- Ruikang Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1016/j.jep.2026.121244
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00