Fusariacumines A C, indole alkaloids from Fusarium acuminatum J207-2 with antibacterial activity

In order to search for antibacterial agents against kiwi plant pathogen Pseudomonas syringae pv. actinidiae (Psa), a Gram-negative bacterium that causes kiwi bacterial canker, three new indole alkaloids, fusariacumines A–C ( 1 – 3 ), together with two known ones ( 5 and 6 ) have been isolated from a kiwi plant-associated fungus Fusarium acuminatum J207–2. Their chemical structures were determined by spectroscopic methods (1D, 2D NMR and HRESIMS). Compounds 1 and 3–5 exhibited moderate anti-Psa activity with minimum inhibitory concentration (MIC) values ranging from 32 to 128 μg/mL. • Five indole alkaloids were obtained from Fusarium acuminatum J207–2. • Three previously unreported compounds were structurally identified. • Four compounds exhibited anti-Psa activity. • It is feasible to find anti-Psa agents from the endophytes of kiwifruit.