Successful Management of Fulminant Immune Checkpoint Inhibitor–Associated Myocarditis Amid Corticosteroid Constraints and Clinical-Biomarker Dissociation
Rebound elevation of troponin T levels may indicate myocardial remodeling rather than active injury, supporting corticosteroid tapering in clinically stable patients. In patients with ICI-associated myocarditis and contraindications to corticosteroids, early steroid tapering combined with alternative immunosuppressive therapy may still achieve favorable outcomes.
Authors
- Jingang Zheng (ORCID: https://orcid.org/0000-0002-3769-6166)
- L N Zhang
- Wenjing Wu (ORCID: https://orcid.org/0000-0001-8479-0895)
- Yanwen Fang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- JACC Case Reports
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1016/j.jaccas.2025.106787
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00