Successful Management of Fulminant Immune Checkpoint Inhibitor–Associated Myocarditis Amid Corticosteroid Constraints and Clinical-Biomarker Dissociation

Rebound elevation of troponin T levels may indicate myocardial remodeling rather than active injury, supporting corticosteroid tapering in clinically stable patients. In patients with ICI-associated myocarditis and contraindications to corticosteroids, early steroid tapering combined with alternative immunosuppressive therapy may still achieve favorable outcomes.

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Publication Details

Journal
JACC Case Reports
Published
2026-01-19
DOI
https://doi.org/10.1016/j.jaccas.2025.106787
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
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article

Successful Management of Fulminant Immune Checkpoint Inhibitor–Associated Myocarditis Amid Corticosteroid Constraints and Clinical-Biomarker Dissociation

Jingang Zheng, L N Zhang, Wenjing Wu, Yanwen Fang
JACC Case Reports
Cancer Immunotherapy and Biomarkers
article

Successful Management of Fulminant Immune Checkpoint Inhibitor–Associated Myocarditis Amid Corticosteroid Constraints and Clinical-Biomarker Dissociation

Jingang Zheng, L N Zhang, Wenjing Wu, Yanwen Fang
article en

Abstract

Rebound elevation of troponin T levels may indicate myocardial remodeling rather than active injury, supporting corticosteroid tapering in clinically stable patients. In patients with ICI-associated myocarditis and contraindications to corticosteroids, early steroid tapering combined with alternative immunosuppressive therapy may still achieve favorable outcomes.

JACC Case ReportsVol. 31(9)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), China-Japan Friendship Hospital (CN), Peking Union Medical College Hospital (CN), Fu Wai Hospital (CN)
Good health and well-being
Openalex Percentile: Top 84%
Cancer Immunotherapy and Biomarkers
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