Fibroblast-like cells accumulate late in human coronary atherosclerosis contributing to necrotic core formation
Putative SMC-derived mesenchymal cells without contractile protein expression expand at the fibroatheroma stage of coronary atherosclerosis. Fibroblast-like cells localize around the necrotic core region and account for many apoptotic cells in plaques, suggesting a role in necrotic core development.
Authors
- V. Labrador (ORCID: https://orcid.org/0000-0001-9907-4998)
- Laura Carramolino (ORCID: https://orcid.org/0000-0002-1661-618X)
- Cecilie Møller (ORCID: https://orcid.org/0000-0002-6524-7608)
- Diana Sharysh (ORCID: https://orcid.org/0000-0003-2173-2772)
- Daniel Morales‐Cano (ORCID: https://orcid.org/0000-0002-1692-4633)
- Jacob Fog Bentzon
- Antonio de Molina
- Julián Albarrán-Juárez
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Spanish National Centre for Cardiovascular Research (ES)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1093/cvr/cvag002
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 44.47