Accurate quantification of anti-drug antibodies against each unique Fab of a bispecific antibody using an ECL bridging assay

By using the combination of a screening and a dual confirmation assay format, we were able to accurately quantify the ADAs against each specific Fab of the bsAb Drug-1.

Authors

Publication Details

Journal
Bioanalysis
Published
2025-12-17
DOI
https://doi.org/10.1080/17576180.2026.2617254
Primary Topic
Monoclonal and Polyclonal Antibodies Research
Type
article
Field-Weighted Citation Impact
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article

Accurate quantification of anti-drug antibodies against each unique Fab of a bispecific antibody using an ECL bridging assay

Ann Schwartz, B. Rowe, Kimberly J. Reese, Amy A Concannon et al.
Bioanalysis
Monoclonal and Polyclonal Antibodies Research
article

Accurate quantification of anti-drug antibodies against each unique Fab of a bispecific antibody using an ECL bridging assay

Ann Schwartz, B. Rowe, Kimberly J. Reese, Amy A Concannon, George R. Gunn, Kelly McGrath
article en

Abstract

By using the combination of a screening and a dual confirmation assay format, we were able to accurately quantify the ADAs against each specific Fab of the bsAb Drug-1.

BioanalysisVol. 17(24)
Good health and well-being
Openalex Percentile: Top 28%
Monoclonal and Polyclonal Antibodies Research
DOIOpen Access PDFOpenAlex
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Accurate quantification of anti-drug antibodies against each unique Fab of a bispecific antibody using an ECL bridging assay — Ann Schwartz, B. Rowe, et al. · Bioanalysis (2025) | TGRS Research Map | TGRS