BDH1 Protects against Diabetic Cardiomyopathy by Improving Mitochondrial Function and Suppressing Cardiomyocyte Apoptosis Via Activation of the AKT/GSK3β Pathway
Our study demonstrates that BDH1 plays a protective role in DCM by regulating BHB level and activating the AKT/GSK3β pathway, thereby mitigating mitochondrial damage and cardiomyocyte apoptosis. BDH1 may be a promising therapeutic target for DCM.
Authors
- Longyan Yang (ORCID: https://orcid.org/0000-0002-0815-5627)
- Jianbo Wu
- Di Wang
- Yanan Cheng
- Yan Wang
- Dong Zhao
- Yu Zhao
Institutions
- Capital Medical University (CN)
- Beijing Luhe Hospital Affiliated to Capital Medical University (CN)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2026-01-19
- DOI
- https://doi.org/10.4093/dmj.2025.0257
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00