Impact of Preanalytical Sample Preparation on the Recovery Rate of Cryopreserved Allogeneic Hematopoietic Stem Cells
Determination of the CD34<sup>+</sup> cell recovery rate after thawing is feasible and may be used as an additional parameter for quality control for cryopreserved allogeneic PBSCs. However, the results of currently used viability assays vary considerably, making comparisons between different cell processing units and cryopreservation protocols difficult. Therefore, available protocols should be carefully evaluated based on "good-manufacturing-practice" (GMP) regulations before implementation.
Authors
- Sabine Käyser (ORCID: https://orcid.org/0000-0003-3796-8843)
- Patrick Wuchter (ORCID: https://orcid.org/0000-0001-9482-2870)
- Karen Bieback (ORCID: https://orcid.org/0000-0003-2621-0703)
- Christina Glas
- Harald Klüter (ORCID: https://orcid.org/0000-0002-5460-2897)
- Philipp Blüm
Institutions
- Heidelberg University (DE)
- German Red Cross (DE)
- University Hospital Heidelberg (DE)
Publication Details
- Journal
- European Journal Of Haematology
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1111/ejh.70118
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00