DNMT gene expression in peripheral leukocytes in schizophrenia and correlations with one-carbon metabolites: folate, total homocysteine, and vitamin B6
These findings suggest a potential correlation between nutritional status and elevated expression of DNMT1 and DNMT3a in schizophrenia. Our findings contribute to the understanding of the epigenetic mechanisms associated with schizophrenia and highlight the need for further investigation of the relationships among gene expression, nutritional status, and psychiatric manifestations.
Authors
- Yui Matsumoto (ORCID: https://orcid.org/0000-0001-9942-9330)
- Masahito Nakataki (ORCID: https://orcid.org/0000-0002-4083-6991)
- Hiroya Matsuda
- Yuichiro Kamiyama
- Yukiko Tomioka (ORCID: https://orcid.org/0000-0002-3466-3035)
- Yuri Yoshida
- Naoki Yamada (ORCID: https://orcid.org/0009-0003-4228-7361)
- Tomohiko Nakayama
- Tomohiro Yoshida
- Hidehiro Umehara (ORCID: https://orcid.org/0000-0002-2375-8899)
- Shusuke Numata
- Mariko Aoki
Institutions
- Tokushima University (JP)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-01-19
- DOI
- https://doi.org/10.3389/fpsyt.2025.1715372
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science