Development of cerebral lateralization in children exposed to fetal antiseizure medications: A prospective cohort study at age 6 years
This cohort reassuringly showed no overall difference in verbal/nonverbal abilities between WWE and HW. Fetal ASM exposure had exposure-dependent effects on manual dexterity. Modifiable factors, including folate supplementation and parental stress, significantly influenced developmental outcomes, underscoring the importance of proactive screening and providing intervention when appropriate.
Authors
- Abigail G. Matthews (ORCID: https://orcid.org/0000-0003-1997-9194)
- D. Loring
- M Cohen
- Angela Birnbaum
- Page B. Pennell
- Kimford J Meador
- Yi Li
- for the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Investigator Group
Institutions
- Emory University (US)
- University of Pittsburgh (US)
- Palo Alto University (US)
- Augusta University (US)
- University of Minnesota System (US)
- Emmes (United States) (US)
- Stanford University (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1002/epi.70103
- Primary Topic
- Hemispheric Asymmetry in Neuroscience
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health