Remote Pancreatic Response to Severe Polytrauma Correlates With Clinical Outcome
Our findings highlight the pancreas as a novel remote responder to severe tissue trauma, even in the absence of direct injury. This widely overlooked dimension of trauma pathophysiology has potential clinical implications. However, further research is essential (i) to unravel the mechanisms driving remote pancreatic enzyme release and (ii) to prove the causality between the pancreatic response and observed clinical parameters.
Authors
- Markus Breunig (ORCID: https://orcid.org/0000-0002-2817-1974)
- C. Morgenstern (ORCID: https://orcid.org/0009-0006-7265-7740)
- Markus Huber‐Lang (ORCID: https://orcid.org/0000-0003-2359-6516)
- Sebastian Wiese (ORCID: https://orcid.org/0000-0001-5697-2608)
- Ludmila Lupu (ORCID: https://orcid.org/0000-0002-0153-9345)
- Paolo Cinelli (ORCID: https://orcid.org/0000-0001-9099-9900)
- Alexander Kleger (ORCID: https://orcid.org/0000-0003-0592-5232)
- Benjamin Mayer (ORCID: https://orcid.org/0000-0003-1042-9006)
- Rebecca Halbgebauer (ORCID: https://orcid.org/0000-0001-8060-2076)
- Lucas Bettac
- Sonja Braumüller
- Daniel Rittirsch (ORCID: https://orcid.org/0000-0002-1185-2431)
- Jonas C. Wrba
- Francesco Roselli
- Thomas Seufferlein
- Hans‐Christoph Pape
- Enes Kumral
- Lisa Wohlgemuth
Institutions
- Universität Ulm (DE)
- Zimmer Biomet (Germany) (DE)
- University Hospital of Zurich (CH)
- Stadtspital Waid (CH)
- University Hospital Ulm (DE)
- Technische Hochschule Ulm (DE)
Publication Details
- Journal
- United European Gastroenterology Journal
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1002/ueg2.70168
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00