Mechano-electrical feedback in transgenic rabbit models of long QT syndrome Type 2 and short QT syndrome Type 1
Mechano-electrical feedback-induced electrical changes, partly mediated by SACs, occur in WT, SQT1, and LQT2, but MEF effects are strongest in LQT2. Mechano-electrical feedback induces pro-arrhythmic effects in silico more prominently in LQT2 and SQT1 than in WT, highlighting the potential pro-arrhythmic role of MEF in a vulnerable electrophysiological substrate.
Authors
- Julien Louradour (ORCID: https://orcid.org/0000-0002-0649-4975)
- Miriam Barbieri (ORCID: https://orcid.org/0009-0002-4589-5998)
- Saranda Nimani (ORCID: https://orcid.org/0000-0002-9298-3678)
- Balázs Ördög (ORCID: https://orcid.org/0000-0002-8971-3079)
- Lucilla Giammarino (ORCID: https://orcid.org/0000-0002-2100-0160)
- Melania Buonocunto (ORCID: https://orcid.org/0000-0002-8581-9052)
- Michael Brunner
- Lluis Matas
- Jordi Heijman
- Tammo Delhaas
- Nicolò Alerni
- Joost Lumens
- Gideon Koren
- K E Odening
- Ruben Lopez
Institutions
- University of Bern (CH)
- Medical University of Graz (AT)
- Brown University (US)
- Maastricht University Medical Centre (NL)
- University Hospital of Bern (CH)
- University Medical Center Freiburg (DE)
- Maastricht University (NL)
- St. Josefskrankenhaus Freiburg (DE)
Publication Details
- Journal
- EP Europace
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1093/europace/euag011
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00