Can microbial profiles influence type II inflammation in chronic rhinosinusitis with nasal polyps?
Dupilumab and surgery-induced favourable microbiota changes by reducing pathogenic bacteria. Nasal microbiota composition may be associated inflammatory and clinical treatment responses in CRSwNP. S. aureus and S. epidermidis correlated with a greater improvement of IgE levels, whereas P. aeruginosa correlated with worse IgE outcomes. Analyzing each patient's nasal microbiome could enable more personalized, microbiome-directed treatment approaches for optimal CRSwNP management.
Authors
- Gaia Vertillo Aluisio (ORCID: https://orcid.org/0000-0003-4534-4176)
- Miguel Mayo-Yáñez (ORCID: https://orcid.org/0000-0002-1829-6597)
- Giovanna Stilo
- Jerome Rene Lechien (ORCID: https://orcid.org/0000-0002-0845-0845)
- Maria SANTAGATI
- Mario Lentini
- Igo La Mantia
- S. Stefani
- A R Sedaghat
- Antonino Maniaci
Institutions
- Western University (CA)
- University of Mons (BE)
- Università degli Studi di Enna Kore (IT)
- University of Catania (IT)
- Complexo Hospitalario Universitario A Coruña (ES)
- University of Cincinnati (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- American Journal of Otolaryngology
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1016/j.amjoto.2026.104786
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00