<scp>NIR</scp> ‐Triggered Antibacterial/Hemostatic Wound Dressing via Facile Fabrication of Thermally Crosslinked <scp>GO</scp> ‐Embedded <scp>PVP</scp> Electrospun Fibers

ABSTRACT Effective hemostasis and pathogenic microorganism clearance are essential primary steps for establishing a stable internal microenvironment during the early stage of wound repair. Therefore, a simultaneous thermal crosslinking‐integration strategy was applied to electrospun polyvinylpyrrolidone (PVP) and graphene oxide nanosheets (GO) composite fibers to achieve early‐stage intervention for acute wounds. During thermal crosslinking, molecular thermal motion facilitates interactions between PVP and GO via various non‐covalent interactions, thereby further stabilizing the macromolecular chains. Specifically, the fabricated PVP‐G5 membranes exhibit robust morphological stability in aqueous environments, enabling them to accommodate excessive wound exudate. As a supporting substrate, the fibrous structure of PVP‐G5 also facilitates platelet accumulation, thereby providing a favorable physical platform for activating the blood coagulation cascade. Furthermore, the embedded GO nanosheets within the fiber matrix not only ensure biocompatibility but also endow the fibrous membranes with NIR‐switched photothermal therapy (PTT), thus achieving broad‐spectrum pathogen eradication. These findings demonstrate that the PVP‐GO composite fiber membranes, fabricated through the in situ thermal integration strategy during crosslinking, offer significant advantages for managing severe bleeding and infection, with promise for early treatment of acute wounds.