Koumine exerts its anti-colorectal cancer effects by disrupting the interaction between HSP90 and CDC37, thereby downregulating downstream signaling pathways

These findings elucidate that koumine exerts potent anti-CRC effects primarily by targeting the HSP90-CDC37 chaperone complex and inhibiting the CDK4/6-Rb signaling axis. This study provides a robust mechanistic foundation and compelling preclinical evidence for the further development of koumine as a promising therapeutic agent for colorectal cancer.