Early Versus Later Anticoagulation After Ischemic Stroke in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Early initiation of DOACs after ischemic stroke in AF appears safe and may modestly reduce stroke recurrence without increasing hemorrhagic or mortality risk. These findings support individualized decision-making and suggest that early anticoagulation is a reasonable strategy in appropriately selected patients.
Authors
- Abdullah Faiz Zaihan (ORCID: https://orcid.org/0000-0001-7241-6767)
- Kaeshaelya Thiruchelvam (ORCID: https://orcid.org/0000-0002-3754-1690)
- Syed Shahzad Hasan (ORCID: https://orcid.org/0000-0002-4058-2215)
- Chia Siang Kow
- Dinesh Sangarran Ramachandram
Institutions
- Monash University Malaysia (MY)
- University of Huddersfield (GB)
- University of Selangor (MY)
- Universiti Teknologi MARA System (MY)
- IMU University (MY)
- Sunway University (MY)
Publication Details
- Journal
- Hospital Pharmacy
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1177/00185787251415491
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00