The Immunoregulatory and Hematopoietic Effects of Momelotinib in a Murine Bone Marrow Failure Model
MMB treatment exacerbated peripheral blood cell reduction and impaired bone marrow hematopoiesis in the immune-mediated AA mouse model. Although MMB modulated T lymphocyte subsets, it did not significantly improve hematopoietic stem and progenitor cell function. These findings highlight the need for further research to explore the potential and limitations of JAK inhibitors like MMB in the treatment of immune-mediated bone marrow failure.
Authors
- Xifeng Dong (ORCID: https://orcid.org/0000-0002-2211-731X)
- Y H Zhang
- Huiqin Zhang (ORCID: https://orcid.org/0000-0003-3179-2066)
- Liping Yang (ORCID: https://orcid.org/0000-0002-9783-8453)
- Huaquan Wang
- Liyan Yang
- Naibo Hu
Institutions
- Tianjin Medical University General Hospital (CN)
- Second Hospital of Tianjin Medical University (CN)
- Tianjin haihe hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Clinical Laboratory Analysis
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1002/jcla.70161
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tianjin Municipal Health Commission
- National Natural Science Foundation of China
- Tianjin Municipal Education Commission
- Tianjin Science and Technology Program