Contrasting Effects of Deep Brain Stimulation and Intravenous Levodopa on Local Field Potentials
Levodopa and stimulation exert distinct but complementary effects on oscillatory activity. FTG, rather than β power alone, reflected therapeutic state and was associated with motor improvement without dyskinesia. These findings highlight FTG as a potential biomarker for adaptive stimulation systems in PD. © 2026 International Parkinson and Movement Disorder Society.
Authors
- Coralie de Hemptinne (ORCID: https://orcid.org/0000-0003-2780-3666)
- Genko Oyama (ORCID: https://orcid.org/0000-0001-7985-5367)
- Hikaru Kamo (ORCID: https://orcid.org/0000-0002-9408-7893)
- Kara A. Johnson (ORCID: https://orcid.org/0000-0001-6556-8957)
- Hirokazu Iwamuro (ORCID: https://orcid.org/0000-0002-9970-6331)
- Jackson N. Cagle (ORCID: https://orcid.org/0000-0002-1955-8050)
- Joshua K. Wong (ORCID: https://orcid.org/0000-0002-4632-3417)
- Mai Shimizu
- Atsushi Umemura
- Taku Hatano
- Masanobu Ito
- Nobutaka Hattori
Institutions
- University of Florida Health (US)
- RIKEN Center for Brain Science (JP)
- University of Florida (US)
- Juntendo University (JP)
Publication Details
- Journal
- Movement Disorders
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1002/mds.70196
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00