Pivotal contribution of super-enhancer-driven KLF6 expression to the adipogenesis of human adipose-derived stem cells
SE activation upregulates KLF6 through PPARγ/p300- and eRNA-mediated transcriptional induction during hADSC adipogenesis. KLF6, in turn, represses DLK1 expression through recruitment of HDAC3 to the promoter and p300 dissociation, thereby facilitating adipocyte differentiation. These findings support a working model in which the epigenetic regulation of KLF6 and DLK1 as a potential therapeutic axis in human obesity.
Authors
- Meng Yuan (ORCID: https://orcid.org/0000-0002-1158-0595)
- Takafumi Aritomi
- Mai-Phuong Nguyen (ORCID: https://orcid.org/0000-0001-9419-5766)
- Uyen Ngo (ORCID: https://orcid.org/0009-0004-0814-2772)
- Kaoru Yamagata (ORCID: https://orcid.org/0000-0002-8125-8630)
- Shigeaki Kato
- Yoshiya Tanaka
- Ngo Thi Dieu Huong
- Shingo Nakayamada
- Hidenori Sakai
- Tong Zhang
- Yu Shan
- Anh Phuong Nguyen
Institutions
- Shenyang Medical College (CN)
- University of Occupational and Environmental Health Japan (JP)
- Sichuan University (CN)
- Hue University (VN)
- VinUniversity (VN)
- Bạch Mai Hospital (VN)
- IRYO Sosei University (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1186/s41232-026-00406-8
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00