The mutual regulation of SOX12 and RNF168 modulates cisplatin resistance in esophageal squamous cell carcinoma cells by regulating DNA damage repair
Collectively, our study identifies a feedback regulatory loop between SOX12 and RNF168 that promotes DNA damage repair and cisplatin resistance in esophageal cancer cells.
Authors
- Zhikai Zeng (ORCID: https://orcid.org/0000-0002-5466-8634)
- Yunhe Huang
- Tianyu Han (ORCID: https://orcid.org/0000-0002-1471-611X)
- Guobin Xie
- Jiangbo Jin
- Bentong Yu
- Yanan Wang
- Ning Wang
- Jie Yang
- Mingshan Liu
- Longhua Sun
- Lun Yang
Institutions
- Nanchang University (CN)
- China-Japan Friendship Hospital (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1186/s13578-025-01505-8
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00