<scp>VPS13A</scp> Deficiency Leads to Impaired Lipid Distribution and Alteration of Mitochondrial Calcium Homeostasis in Fibroblasts of <scp>VPS13A</scp> Disease Patients
Loss of VPS13A causes alterations beyond an impairment of lipid shuttling, which includes a dysregulation of membrane contact sites as well as impaired mitochondrial calcium handling. Accordingly, our findings contribute significantly to the understanding of mechanisms directly or indirectly linked to the function of VPS13A. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Jenny Leopold (ORCID: https://orcid.org/0000-0002-4993-5136)
- Dajana Großmann (ORCID: https://orcid.org/0000-0002-2005-4546)
- Sebastian Klicker
- Adrian Spranger
- Kevin Peikert
- Hannes Glaß
- Johanna W. Schubarth
- Emily Fischer
- Andreas Hermann
- Anna Elisabeth Bartalis
- My Uyen Dang Thi
Institutions
- German Center for Neurodegenerative Diseases (DE)
- University of Rostock (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1002/mds.70177
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Hermann und Lilly Schilling-Stiftung für Medizinische Forschung
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung