Rs12516 A allele elevates the risk of colorectal cancer via functional CeRNA network of BDNF-AS, miR-4704-5p and BRCA1
BRCA1 rs12516 is characterized as a potential biomarker associated with CRC risk, via a possible functional ceRNA network of BDNF-AS, miR-4704-5p and BRCA1. The interaction of a lower expression of BDNF-AS, a higher expression of miR-4704-5p and rs12516 A allele could together increase the risk of colorectal cancer.
Authors
- Zhijun Fan
- Xiaoxia Li (ORCID: https://orcid.org/0000-0003-3972-9715)
- Daxu Liu
- Jihong Wu
- Cui Ming
- Xiaobo Lu
- Deyu Sun
- Teng Zhang
Institutions
- Fourth Affiliated Hospital of China Medical University (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1186/s12885-025-14692-x
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00