Postmortem Serum Prostate-Specific Antigen as a Potential Marker for Prostatic Disease: A Forensic Exploratory Study

Postmortem serum PSA may serve as a supportive adjunctive indicator of underlying prostatic pathology in forensic autopsies; however, its diagnostic performance - particularly for distinguishing benign disease from normal aging - appears limited. These findings should be regarded as hypothesis-generating and require confirmation in larger multicenter cohorts. The primary objective was to explore whether postmortem serum PSA differs among PCa, BPH, and control cases, and the secondary objectives were to examine its relationships with age and PMI and the postmortem stability of PSA.