E3 ubiquitin ligase trim36 targets ddx3x for degradation to reprogram macrophage polarization and ameliorate tubal factor infertility in rats
This study identifies TRIM36 as a novel E3 ligase that targets DDX3X for proteasomal degradation, thereby driving macrophage M2 polarization and ameliorating TFI. The TRIM36/DDX3X axis may provide a promising therapeutic target for TFI treatment.
Authors
- Qiongfang Tan
- Liang Shao (ORCID: https://orcid.org/0000-0001-9066-8503)
- Yan Yan
- Yuying Huang
- Ling Liu
- Qin Wu
- Yali Tan
- Nansu Wang
- Can Zhao
Institutions
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Hunan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1007/s10565-026-10140-z
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00