Glypican 3-targeted chimeric antigen receptor T cells secreting TROP2-directed bispecific T cell engagers exhibit potent efficacy against lung squamous cell carcinoma

This study demonstrated that GPC3 CAR-T. TROP2 BiTE was a potent therapy for LUSC and provided a strategy for overcoming the antigen heterogeneity in solid tumors.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-19
DOI
https://doi.org/10.3389/fimmu.2025.1709316
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
0.00
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article

Glypican 3-targeted chimeric antigen receptor T cells secreting TROP2-directed bispecific T cell engagers exhibit potent efficacy against lung squamous cell carcinoma

Lianjie Ruan, Mao Lin, Suiyan Weng, Liming Lin et al.
Frontiers in Immunology
CAR-T cell therapy research
article

Glypican 3-targeted chimeric antigen receptor T cells secreting TROP2-directed bispecific T cell engagers exhibit potent efficacy against lung squamous cell carcinoma

Lianjie Ruan, Mao Lin, Suiyan Weng, Liming Lin, Dekai Lin, Haiqing Zhang
article en

Abstract

This study demonstrated that GPC3 CAR-T. TROP2 BiTE was a potent therapy for LUSC and provided a strategy for overcoming the antigen heterogeneity in solid tumors.

Frontiers in ImmunologyVol. 16
Putian University (CN)
Good health and well-being
Openalex Percentile: Top 84%
CAR-T cell therapy research
DOIOpen Access PDFOpenAlex
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