The Impact of VDR Gene and Biochemical Indicators in Osteoporosis

Osteoporosis is a disorder caused by bone remodeling imbalance in which bone resorption outpaces bone production, resulting in weaker bone structure. Factors such as heredity and insufficient calcium and vitamin D consumption. This study included an examination of 80 female patients of different ages (40–58 years) in Mosul. The participants were divided into two groups: 20 individuals served as the control group, while the rest 60 were osteoporotic women based on clinical cases and taking X ray DEXA. The blood samples are divided into two parts serum for biochemical tests and blood for genetic diversity in genes associated to Vitamin D Receptor (VDR) was then examined. The results indicated the presence of mutations in the VDR gene at location (rs7975232). Furthermore, an observed variance in numbers of nucleotide after sequencing. there was also a significant decrease in vitamin D and Calcium levels in the blood serum of osteoporotic woman as compared to the control group.