The Cap-Independent Translation of Survivin 5′UTR and HIV-1 IRES Sequences Is Inhibited by Oxidative Stress Produced by H. pylori Gamma-Glutamyl Transpeptidase Activity
The Survivin 5'UTR exhibits cap-independent translation activity that is inhibited by <i>H. pylori</i> in a GGT-dependent manner, likely via oxidative stress. This mechanism helps to explain the downregulation of Survivin during gastric infection and indicates that oxidative stress can negatively affect both cellular and viral IRES-mediated translation.
Authors
- Esteban Palacios (ORCID: https://orcid.org/0000-0003-0272-9631)
- A. G. Quest
- Manuel A. J. Valenzuela (ORCID: https://orcid.org/0000-0002-8833-7382)
- J. Villena (ORCID: https://orcid.org/0000-0002-4706-5341)
- Nicolás Carrasco-Véliz
- Maritza P. Garrido (ORCID: https://orcid.org/0000-0001-7234-3916)
- Maria Izabel Gomès Silva
- Iván Montenegro
- María Fernanda González
- Mariaignacia Rubilar
Institutions
- Viña del Mar University (CL)
- Centro de Recursos Educativos Avanzados (CL)
- Hospital Clínico de la Universidad de Chile (CL)
- Universidad Central de Chile (CL)
- University of Chile (CL)
Publication Details
- Journal
- Biomolecules
- Published
- 2026-01-19
- DOI
- https://doi.org/10.3390/biom16010164
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00