Sirtuins and Cartilage Preservation: From Cellular Function to Therapeutic Innovation

The bones are cushioned by a thin layer of hyaline cartilage that permits physical activity to be performed without experiencing any discomfort. However, these tissues are susceptible to several diseases involving osteoarthritis and rheumatoid arthritis resulting in cartilage degradation. Sirtuins (SRTs) and SRT-activating molecules have been shown in previous studies to affect cartilage and chondrocytes positively. This review aims to explore the potential protective effects of SRTs on cartilage and chondrocytes. It also highlighting various SRT-activating substances and their potential therapeutic applications in managing cartilage-related diseases. Google Scholar, Cochrane Library, and PubMed were used to search about related studies. The impacts of SRTs on cartilage and chondrocytes are beneficial. Additionally, numerous SRT-activating substances may enhance chondrocyte viability and cartilage anabolism which provide a potential therapeutic option in the management of cartilage-related diseases. However, additional studies are essential to clarify the effectiveness of such candidates in the treatment of these diseases.