Population portrait of the atrial fibrillation by the ESSE-RF study. Part 2. The relationship of atrial fibrillation with diseases and biological indicators

The study of parameters associated with atrial fibrillation (AF) is necessary for optimal organization of prevention of this potentially adverse cardiac arrhythmia. Objective. To perform an analysis of the association of atrial fibrillation with diseases and biological parameters according to the ESSE-RF population study. Materials and methods. The analysis was carried out on the material of «Epidemiology of Cardiovascular Diseases in regions of the Russian Federation (ESSE-RF)» multicenter epidemiological study — 17693 persons (38.4% men) aged 25—64 years, among them 116 had AF. Univariate and multivariate logistic regression, adjusted for sex and age, were used to evaluate the relationship of the analyzed parameters with AF. Materials and methods are presented in details in the first part of the article. Results. According to the results of univariate analysis, AF is associated with the presence of arterial hypertension, diabetes mellitus, ischemic heart disease and obesity as well as with a heart rate (HR) >80 b/min and high blood pressure. In addition, the relationship of AF with increased content of uric acid, creatinine, high-sensitivity C-reactive protein, brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and decreased high-density lipoprotein cholesterol level has been determined. Based on the multivariate analysis results, only levels of two biomarkers — BNP and cTnI — were independently associated with the presence of AF. Conclusion. In the Russian population of working age, the relationships of atrial fibrillation with diseases and biological parameters have been studied. Independent associations with atrial fibrillation have been identified only for brain natriuretic peptide and cardiac troponin I. Appearingly, changes in atrial fibrillation related to cardiomyocyte damage and heart remodeling may be more significant than changes in other biological parameters and changes associated with the presence of specific diseases. The obtained result is consistent with the concept of atrial fibrillation pathogenesis.