Simulated lung exposure in pneumonia patients to evaluate the antibacterial capacity and resistance suppression of clinical tigecycline regimens against carbapenem-resistant <i>Acinetobacter baumannii</i>
While high-dose tigecycline enhanced antibacterial efficacy, its failure to prevent efflux-mediated resistance in specific strains highlights the inherent limitations of dose escalation for CRAB pneumonia treatment.
Authors
- Xiaomin Fang (ORCID: https://orcid.org/0000-0002-7563-5268)
- Sanwang Li (ORCID: https://orcid.org/0000-0001-5979-5133)
- Yehua Xie
- Hanxi Yi
- Feiyan Liu
- Zeneng Cheng
- Feifan Xie
Institutions
- Central South University (CN)
- SGIDI Engineering Consulting (China) (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/jac/dkaf477
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00