Comparison of Clinical Features and Hemodynamics of Single Ventricle Patients With and Without Interventional Closure of Veno-Venous or Aortopulmonary Collaterals

In single ventricle (SV) patients, veno-venous (VVCs) and major aortopulmonary collaterals (APCs) are common. We aim to determine the differences between patients with and without interventional closure of VVCs or APCs in this single-center, retrospective analysis of 135 SV patients (2006-2021). Anatomical, surgical and clinical features, hemodynamics and PA dimensions were compared. VVC closure was performed in 34 (25%) patients. VVC closure was associated with comprehensive stage I + II ( = 0.05), left PA patch procedure ( = 0.04), Fontan fenestration ( /= 16 mmHg pre-BCPC ( = 0.04) and >/= 15 mmHg pre-TCPC ( = 0.021), lower saturation pre-TCPC ( = 0.04) and smaller PAs (Nakata = 0.03, total lower lobe index = 0.001). Patients with VVC closure had a longer hospitalization post-BCPC ( = 0.008) and post-TCPC ( = 0.04) and longer ICU time post-BCPC ( = 0.04). APC closure was performed in 53 (39%) patients. Male sex ( = 0.001), Norwood I procedure ( = 0.04), younger age at BCPC ( = 0.02), higher end-diastolic pressure pre-TCPC ( = 0.04), lower oxygen levels pre-BCPC ( < 0.001) and smaller PAs (Nakata = 0.08; McGoon < 0.001) were related to APC closure. Patients with APC closure had a longer hospital ( < 0.001) and ICU ( = 0.005) stay post-TCPC. Significant VVC and APCs are linked to poorer PA growth, worse hemodynamics, lower sats and prolonged hospital/ICU stays, highlighting the need for targeted attention.