Ceftazidime/avibactam: a potent arsenal against multidrug-resistant <i>Pseudomonas aeruginosa</i> -unveiling <i>in vitro</i> and <i>in vivo</i> strategies

Combining ceftazidime/avibactam with polymyxin B might represent a potentially effective option against MDR-P.aeruginosa. Although the synergistic effect in vitro might not be readily apparent due to the potent bactericidal effect of aztreonam alone, the combination of ceftazidime/avibactam and aztreonam demonstrated promising synergistic effects on MBL-positive P.aeruginosa strains in vivo.