Semaphorin 7A aggravates abdominal aortic aneurysm through PDK1/SGK3/YTHDC1 axis-mediated phenotypic switching of vascular smooth muscle cells
This study underscores the critical role of SEMA7A in regulating VSMC phenotypic switching through a novel PDK1/SGK3/YTHDC1 axis, which contributes to AAA pathogenesis, suggesting that targeting SEMA7A is a promising therapeutic strategy for AAA prevention and treatment.
Authors
- Lili Wu (ORCID: https://orcid.org/0000-0002-1319-7274)
- Fengchan Li (ORCID: https://orcid.org/0000-0002-4631-1651)
- Fan Tang (ORCID: https://orcid.org/0000-0003-3074-2198)
- Qiongyu Lu
- Du Yun
- Hongjie Wang (ORCID: https://orcid.org/0000-0002-5125-1307)
- Lijie Ren (ORCID: https://orcid.org/0000-0001-9756-2226)
- Jiaxin Lyu
- Zhen Zhu
- Lei Hong
- Li Zhu
- Chaojun Tang
- Ying Wang
- Haofu Ni
- Huihui Liu
Institutions
- Anhui Medical University (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- First Affiliated Hospital of Soochow University (CN)
- Huazhong University of Science and Technology Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1093/cvr/cvag009
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00