Human umbilical cord mesenchymal stem cells alleviate colon epithelial apoptosis in ulcerative colitis by activating inositol-requiring enzyme 1/X-box binding protein 1 signaling

Our findings demonstrate that hUC-MSCs alleviate UC by mitigating ER stress through IRE1-mediated Xbp1 splicing, thereby reducing epithelial apoptosis and promoting mucosal repair. This study provides a mechanistic foundation for MSC-based therapies targeting ER stress in inflammatory bowel diseases.

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Publication Details

Journal
Stem Cells Translational Medicine
Published
2025-12-30
DOI
https://doi.org/10.1093/stcltm/szaf075
Primary Topic
Mesenchymal stem cell research
Type
article
Field-Weighted Citation Impact
0.00
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article

Human umbilical cord mesenchymal stem cells alleviate colon epithelial apoptosis in ulcerative colitis by activating inositol-requiring enzyme 1/X-box binding protein 1 signaling

X Zhang, Taoran Zhao, Shulin Hou, M Wang et al.
Stem Cells Translational Medicine
Mesenchymal stem cell research
article

Human umbilical cord mesenchymal stem cells alleviate colon epithelial apoptosis in ulcerative colitis by activating inositol-requiring enzyme 1/X-box binding protein 1 signaling

X Zhang, Taoran Zhao, Shulin Hou, M Wang, Xiaoni Feng, Kai Zheng, Xiujuan Li, Hong Zhao, Wenyi Hou, Heng Wang, Zhenyu Feng, Jun Xie
article en

Abstract

Our findings demonstrate that hUC-MSCs alleviate UC by mitigating ER stress through IRE1-mediated Xbp1 splicing, thereby reducing epithelial apoptosis and promoting mucosal repair. This study provides a mechanistic foundation for MSC-based therapies targeting ER stress in inflammatory bowel diseases.

Stem Cells Translational MedicineVol. 15(1)
Shanxi Medical University (CN), Shanxi Province Hospital of Traditional Chinese Medicine (CN), Westmead Institute for Medical Research (AU)
Good health and well-being
Openalex Percentile: Top 24%
Mesenchymal stem cell research
DOIOpen Access PDFOpenAlex
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Human umbilical cord mesenchymal stem cells alleviate colon epithelial apoptosis in ulcerative colitis by activating inositol-requiring enzyme 1/X-box binding protein 1 signaling — X Zhang, Taoran Zhao, et al. · Stem Cells Translational Medicine (2025) | TGRS Research Map | TGRS