Cross-reactive H5N1 Neuraminidase Antibodies by Age and Influenza A Imprinting Cohorts of the Past Century: Population-Based Serosurvey, British Columbia, Canada
A substantial proportion of the population has pre-existing anti-N1 against H5N1, with age-related variation reflecting H1N1 imprinting and exposure opportunities. Through heightened attack rates and shifts in immunological hierarchies, historic pandemics shape and expand the immune repertoire with implications for pre-immunity to emerging zoonotic threats.
Authors
- Johnny Ung
- Charlene Ranadheera (ORCID: https://orcid.org/0000-0002-5674-7061)
- Darwyn Kobasa (ORCID: https://orcid.org/0000-0002-6371-7493)
- Romina C. Reyes
- Samantha E Kaweski
- N Bastien
- Suzana Sabaiduc
- Felicity Clemens
- Lea Separovic
- Danuta M Skowronski
- Gaby Makowski
- Bonnie Henry
Institutions
- Ministry of Health (CA)
- Public Health Agency of Canada (CA)
- BC Centre for Disease Control (CA)
- Innovative Targeting Solutions (Canada) (CA)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1093/infdis/jiag030
- Citations
- 2
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 63.04